The pulmonary vasculature - lessons from Tibetans and from rare diseases of oxygen sensing.
The human pulmonary circulation loses its natural distensibility during sustained hypoxia, leading to pulmonary arterial hypertension and a much higher workload for the right ventricle. The hypoxia-inducible factor (HIF) pathway is implicated in this pulmonary vascular response to continued hypoxia...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2014
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