Active adenoviral vascular penetration by targeted formation of heterocellular endothelial-epithelial syncytia.

The endothelium imposes a structural barrier to the extravasation of systemically delivered oncolytic adenovirus (Ad). Here, we introduced a transendothelial route of delivery in order to increase tumor accumulation of virus particles (vp) beyond that resulting from convection-dependent extravasatio...

Ausführliche Beschreibung

Bibliographische Detailangaben
Hauptverfasser: Chen, H, Cawood, R, El-Sherbini, Y, Purdie, L, Bazan-Peregrino, M, Seymour, L, Carlisle, R
Format: Journal article
Sprache:English
Veröffentlicht: 2011