The ubiquitin-selective segregase VCP/p97 orchestrates the response to DNA double-strand breaks.
Unrepaired DNA double-strand breaks (DSBs) cause genetic instability that leads to malignant transformation or cell death. Cells respond to DSBs with the ordered recruitment of signalling and repair proteins to the site of lesion. Protein modification with ubiquitin is crucial for the signalling cas...
| Główni autorzy: | , , , , , , , , , |
|---|---|
| Format: | Journal article |
| Język: | English |
| Wydane: |
2011
|