Polyamines control eIF5A hypusination, TFEB translation, and autophagy to reverse B cell senescence

Polyamines control eIF5A hypusination, TFEB translation, and autophagy to reverse B cell senescence

Failure to make adaptive immune responses is a hallmark of aging. Reduced B cell function leads to poor vaccination efficacy and a high prevalence of infections in the elderly. Here we show that reduced autophagy is a central molecular mechanism underlying immune senescence. Autophagy levels are spe...

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التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Zhang, H, Alsaleh, G, Feltham, J, Sun, Y, Napolitano, G, Riffelmacher, T, Charles, P, Frau, L, Hublitz, P, Yu, Z, Mohammed, S, Ballabio, A, Balabanov, S, Mellor, J, Simon, A
التنسيق: Journal article
اللغة:English
منشور في: Cell Press 2019

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