Polyamines control eIF5A hypusination, TFEB translation, and autophagy to reverse B cell senescence
Failure to make adaptive immune responses is a hallmark of aging. Reduced B cell function leads to poor vaccination efficacy and a high prevalence of infections in the elderly. Here we show that reduced autophagy is a central molecular mechanism underlying immune senescence. Autophagy levels are spe...
Asıl Yazarlar: | Zhang, H, Alsaleh, G, Feltham, J, Sun, Y, Napolitano, G, Riffelmacher, T, Charles, P, Frau, L, Hublitz, P, Yu, Z, Mohammed, S, Ballabio, A, Balabanov, S, Mellor, J, Simon, A |
---|---|
Materyal Türü: | Journal article |
Dil: | English |
Baskı/Yayın Bilgisi: |
Cell Press
2019
|
Benzer Materyaller
-
Polyamine biosynthesis and eIF5A hypusination are modulated by the DNA tumor virus KSHV and promote KSHV viral infection.
Yazar:: Guillaume N Fiches, ve diğerleri
Baskı/Yayın Bilgisi: (2022-04-01) -
Role of Polyamines and Hypusine in β Cells and Diabetes Pathogenesis
Yazar:: Abhishek Kulkarni, ve diğerleri
Baskı/Yayın Bilgisi: (2022-04-01) -
Polyamines and eIF5A hypusination facilitate SREBP2 synthesis and cholesterol production leading to enhanced enterovirus attachment and infection.
Yazar:: Mason R Firpo, ve diğerleri
Baskı/Yayın Bilgisi: (2023-04-01) -
Polyamine and EIF5A hypusination downstream of c-Myc confers targeted therapy resistance in BRAF mutant melanoma
Yazar:: Byung-Sun Park, ve diğerleri
Baskı/Yayın Bilgisi: (2024-07-01) -
P53-dependent hypusination of eIF5A affects mitochondrial translation and senescence immune surveillance
Yazar:: Xiangli Jiang, ve diğerleri
Baskı/Yayın Bilgisi: (2024-08-01)