A humanized version of Foxp2 affects cortico-basal ganglia circuits in mice.

It has been proposed that two amino acid substitutions in the transcription factor FOXP2 have been positively selected during human evolution due to effects on aspects of speech and language. Here, we introduce these substitutions into the endogenous Foxp2 gene of mice. Although these mice are gener...

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Bibliographic Details
Main Authors:	Enard, W, Gehre, S, Hammerschmidt, K, Hölter, S, Blass, T, Somel, M, Brückner, M, Schreiweis, C, Winter, C, Sohr, R, Becker, L, Wiebe, V, Nickel, B, Giger, T, Müller, U, Groszer, M, Adler, T, Aguilar, A, Bolle, I, Calzada-Wack, J, Dalke, C, Ehrhardt, N, Favor, J, Fuchs, H, Gailus-Durner, V
Format:	Journal article
Language:	English
Published:	2009

A humanized version of Foxp2 affects cortico-basal ganglia circuits in mice.

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