β-PrP form of human prion protein stimulates production of monoclonal antibodies to epitope 91–110 that recognise native PrPSc
Prion diseases are associated with accumulation of strain-dependent biochemically distinct, disease-related isoforms (PrPSc) of host-encoded prion protein (PrPC). PrPSc is characterised by increased β-sheet content, detergent insolubility and protease resistance. Recombinant α-PrP adopts a PrPC-like...
| Main Authors: | , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Elsevier
2007
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