β-PrP form of human prion protein stimulates production of monoclonal antibodies to epitope 91–110 that recognise native PrPSc

β-PrP form of human prion protein stimulates production of monoclonal antibodies to epitope 91–110 that recognise native PrPSc

Prion diseases are associated with accumulation of strain-dependent biochemically distinct, disease-related isoforms (PrPSc) of host-encoded prion protein (PrPC). PrPSc is characterised by increased β-sheet content, detergent insolubility and protease resistance. Recombinant α-PrP adopts a PrPC-like...

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Bibliographic Details
Main Authors:	Khalili-Shirazi, A, Kaisar, M, Mallinson, G, Jones, S, Bhelt, D, Fraser, C, Clarke, AR, Hawke, SH, Jackson, GS, Collinge, J
Format:	Journal article
Language:	English
Published:	Elsevier 2007

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