Impaired regulation of neuronal nitric oxide synthase and heart rate during exercise in mice lacking one nNOS allele.

Impaired regulation of neuronal nitric oxide synthase and heart rate during exercise in mice lacking one nNOS allele.

We tested the hypothesis that a single allele deletion of neuronal nitric oxide synthase (nNOS) would impair the neural control of heart rate following physical training, and that this phenotype could be restored following targeted gene transfer of nNOS. Voluntary wheel-running (+EX) in heterozygous...

Podrobná bibliografie
Hlavní autoři:	Danson, E, Mankia, K, Golding, S, Dawson, T, Everatt, L, Cai, S, Channon, K, Paterson, D
Médium:	Journal article
Jazyk:	English
Vydáno:	2004

Podobné jednotky

Impaired regulation of neuronal nitric oxide synthase during exercise abolishes training-induced facilitation of cardiac vagal function in mice lacking one nNOS allele
Autor: Danson, E, a další
Vydáno: (2003)

Cardiac nitric oxide: emerging role for nNOS in regulating physiological function.
Autor: Danson, E, a další
Vydáno: (2005)

Targeted nNOS gene transfer into the cardiac vagus rapidly increases parasympathetic function in the pig.
Autor: Heaton, D, a další
Vydáno: (2005)

Neuronal Nitric Oxide Synthase (nNOS) Regulates Basal Flow in the Human Coronary Circulation In Vivo
Autor: Seddon, M, a další
Vydáno: (2008)

Inhibition of interferon-gamma-stimulated melanoma progression by targeting neuronal nitric oxide synthase (nNOS)
Autor: Shirley Tong, a další
Vydáno: (2022-02-01)

Targeting neuronal nitric oxide synthase with gene transfer to modulate cardiac autonomic function.
Autor: Mohan, R, a další
Vydáno: (2004)

Gene transfer of neuronal nitric oxide synthase into intracardiac Ganglia reverses vagal impairment in hypertensive rats.
Autor: Heaton, D, a další
Vydáno: (2007)

Assessment of tamoxifen effects on nitric oxide synthase (nNOS) in rat developing hippocampus
Autor: Tabatabaeei Parvaneh, a další
Vydáno: (2008-07-01)

Neuronal nitric oxide synthase gene transfer promotes cardiac vagal gain of function.
Autor: Mohan, R, a další
Vydáno: (2002)

Adenoviral nNOS gene transfer into the cardiac vagus increases protein expression within 9 hours and enhances vagal responsiveness in the pig
Autor: Paterson, D, a další
Vydáno: (2004)

Neuronal nitric oxide synthase (nnos) expression following inferior alveolar nerve injury.
Autor: Davies, S, a další
Vydáno: (2003)

Discordant response to exercise training in nnos knockout mice: Differential role of nNOS on exercise performance versus cardiac hypertrophy
Autor: de Bono, J, a další
Vydáno: (2007)

Enhanced neuronal nitric oxide synthase expression is central to cardiac vagal phenotype in exercise-trained mice.
Autor: Danson, E, a další
Vydáno: (2003)

The heart is an early target of anthrax lethal toxin in mice: a protective role for neuronal nitric oxide synthase (nNOS).
Autor: Mahtab Moayeri, a další
Vydáno: (2009-05-01)

Selective gene deletion of the neuronal nitric oxide synthase (nNOS) accelerates pathological left ventricular remodelling and functional deterioration after myocardial infarction (MI)
Autor: Dawson, D, a další
Vydáno: (2005)

Differential role of nNOS in heart rate regulation between rest and exercise
Autor: Adlam, D, a další
Vydáno: (2007)

Neuronal nitric oxide synthase-rescue of dystrophin/utrophin double knockout mice does not require nNOS localization to the cell membrane.
Autor: Michelle Wehling-Henricks, a další
Vydáno: (2011-01-01)

Nitric oxide synthase (nNOS) gene transfer modifies venous bypass graft remodeling: effects on vascular smooth muscle cell differentiation and superoxide production.
Autor: West, N, a další
Vydáno: (2001)

A critical role for neuronal nitric oxide synthase in the Physiologic response to exercise
Autor: De Bono, J, a další
Vydáno: (2007)

Tetrahydrobiopterin (BH4), a cofactor for nNOS, restores gastric emptying and nNOS expression in female diabetic rats.
Autor: Gangula, P, a další
Vydáno: (2010)

Confocal Laser Scanning Microscopy on the Distribution of Neural Nitric Oxide Synthase (nNOS)-immunoreactive Nerves in the Chicken Harderian Gland
Autor: Kohzy Hiramatsu, a další
Vydáno: (2005-02-01)

Targeting cardiac sympatho-vagal imbalance using gene transfer of nitric oxide synthase.
Autor: Danson, E, a další
Vydáno: (2009)

Phenotyping of nNOS neurons in the postnatal and adult female mouse hypothalamus
Autor: Chachlaki, K, a další
Vydáno: (2017)

The expanding roles of neuronal nitric oxide synthase (NOS1)
Autor: Kundan Solanki, a další
Vydáno: (2022-07-01)

Neuronal nitric oxide synthase (NOS I) in the buffalo epididymis
Autor: E. Langella, a další
Vydáno: (2010-02-01)

Neuronal NOS (nNOS) is expressed in human osteocytes: Multiple pathways of NO regulation?
Autor: Caballero, A, a další
Vydáno: (2002)

High nitrate levels in skeletal muscle contribute to nitric oxide generation via a nitrate/nitrite reductive pathway in mice that lack the nNOS enzyme
Autor: Supranee Upanan, a další
Vydáno: (2024-05-01)

Targeted neuronal nitric oxide synthase transgene delivery into stellate neurons reverses impaired intracellular calcium transients in prehypertensive rats
Autor: Li, D, a další
Vydáno: (2013)

Characteristics of colonic migrating motor complexes in neuronal NOS (nNOS) knockout mice
Autor: Nick eSpencer
Vydáno: (2013-10-01)

Reduced phospholamban phosphorylation is responsible for impaired myocardial relaxation in nNOS(-/-) mice
Autor: Zhang, Y, a další
Vydáno: (2005)

Targeted neuronal nitric oxide synthase transgene delivery into stellate neurons reverses impaired intracellular calcium transients in prehypertensive rats.
Autor: Li, D, a další
Vydáno: (2013)

Effect of in vivo gene transfer of nNOS in the PVN on renal nerve discharge in rats.
Autor: Li, Y, a další
Vydáno: (2002)

Regulation of endothelial nitric oxide synthase (eNOS) by tetrahydrobiopterin in vascular disease
Autor: Alp, N, a další
Vydáno: (2004)

Cardiac cholinergic NO-cGMP signaling following acute myocardial infarction and nNOS gene transfer.
Autor: Dawson, T, a další
Vydáno: (2008)

nNOS gene transfer to RVLM improves baroreflex function in rats with chronic heart failure.
Autor: Wang, Y, a další
Vydáno: (2003)

Insulin resistance in mice lacking neuronal nitric oxide synthase is related to an alpha-adrenergic mechanism
Autor: P Turini, a další
Vydáno: (2007-12-01)

Endothelial nitric oxide synthase dysfunction in diabetic mice: importance of tetrahydrobiopterin in eNOS dimerisation.
Autor: Cai, S, a další
Vydáno: (2005)

Reduced phospholamban phosphorylation is responsible for impaired myocardial relaxation in nNOS(-/-) mice
Autor: Zhang, Y, a další
Vydáno: (2006)

Long-term effect of neuronal nitric oxide synthase over-expression on cardiac neurotransmission mediated by a lentiviral vector.
Autor: Wang, L, a další
Vydáno: (2009)

Tetrahydrobiopterin and nitric oxide synthase recouplers
Autor: Channon, KM
Vydáno: (2020)