Heat shock protein 70 promotes cancer cell viability by safeguarding lysosomal integrity.
The major heat-inducible Hsp70 is a potent survival protein that confers cytoprotection against numerous death-inducing stimuli and increases the tumorigenicity of rodent cells. The depletion of Hsp70 by adenovirus-mediated transfer of antisense cDNA induces caspase-independent death of tumorigenic...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2004
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