Heat shock protein 70 promotes cancer cell viability by safeguarding lysosomal integrity.
The major heat-inducible Hsp70 is a potent survival protein that confers cytoprotection against numerous death-inducing stimuli and increases the tumorigenicity of rodent cells. The depletion of Hsp70 by adenovirus-mediated transfer of antisense cDNA induces caspase-independent death of tumorigenic...
Váldodahkkit: | , , |
---|---|
Materiálatiipa: | Journal article |
Giella: | English |
Almmustuhtton: |
2004
|