Stereoselective synthesis of cyclohexanes via an iridium catalyzed (5 + 1) annulation strategy

An iridium catalyzed method for the synthesis of functionalized cyclohexanes from methyl ketones and 1,5-diols is described. This process operates by two sequential hydrogen borrowing reactions, providing direct access to multisubstituted cyclic products with high levels of stereocontrol. This metho...

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Bibliographic Details
Main Authors: Akhtar, WM, Armstrong, RJ, Frost, JR, Stevenson, NG, Donohoe, TJ
Format: Journal article
Language:English
Published: American Chemical Society 2018