Subtraction-free and bisulfite-free specific sequencing of 5-methylcytosine and its oxidized derivatives at base resolution

Although various methods have been developed for sequencing cytosine modifications, it is still challenging for specific and quantitative sequencing of individual modification at base-resolution. For example, to obtain both true 5-methylcytosine (5mC) and true 5-hydroxymethylcytosine (5hmC) informat...

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Main Authors: Liu, Y, Hu, Z, Cheng, J, Siejka-Zielinska, P, Chen, J, Inoue, M, Ahmed, A, Song, C
格式: Journal article
语言:English
出版: Springer Nature 2021