Adult onset global loss of the FTO gene alters body composition and metabolism in the mouse

The strongest BMI-associated GWAS locus in humans is the FTO gene. Rodent studies demonstrate a role for FTO in energy homeostasis and body composition. The phenotypes observed in loss of expression studies are complex with perinatal lethality, stunted growth from weaning, and significant alteration...

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Detalhes bibliográficos
Principais autores: McMurray, F, Church, C, Larder, R, Nicholson, G, Wells, S, Teboul, L, Tung, Y, Rimmington, D, Bosch, F, Jimenez, V, Yeo, G, O'Rahilly, S, Ashcroft, F, Coll, A, Cox, R
Formato: Journal article
Idioma:English
Publicado em: Public Library of Science 2013