ADGRE1 (EMR1, F4/80) Is a rapidly-evolving gene expressed in mammalian monocyte-macrophages

The F4/80 antigen, encoded by the Adgre1 locus, has been widely-used as a monocyte-macrophage marker in mice, but its value as a macrophage marker in other species is unclear, and has even been questioned. ADGRE1 is a seven transmembrane G protein-coupled receptor with an extracellular domain contai...

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Bibliographic Details
Main Authors: Waddell, L, Lefevre, L, Bush, S, Raper, A, Young, R, Lisowski, Z, McCulloch, M, Muriuki, C, Sauter, K, Clark, E, Irvine, K, Pridans, C, Hope, J, Hume, D
Format: Journal article
Language:English
Published: Frontiers Media 2018