Validation of a chloroquine-induced cell death mechanism for clinical use against malaria.

Validation of a chloroquine-induced cell death mechanism for clinical use against malaria.

An alternative antimalarial pathway of an 'outdated' drug, chloroquine (CQ), may facilitate its return to the shrinking list of effective antimalarials. Conventionally, CQ is believed to interfere with hemozoin formation at nanomolar concentrations, but resistant parasites are able to effl...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς:	Ch'ng, J, Lee, Y, Gun, S, Chia, W, Chang, Z, Wong, L, Batty, K, Russell, B, Nosten, F, Renia, L, Tan, K
Μορφή:	Journal article
Γλώσσα:	English
Έκδοση:	Nature Publishing Group 2014
Θέματα:	Malaria Pharmacology

Παρόμοια τεκμήρια

Evaluation of chloroquine therapy for vivax and falciparum malaria in southern Sumatra, western Indonesia
ανά: Sutanto, I, κ.ά.
Έκδοση: (2010)

World Antimalarial Resistance Network I: Clinical efficacy of antimalarial drugs
ανά: Price, R, κ.ά.
Έκδοση: (2007)

Malaria : obstacles and opportunities /
ανά: Institute of Medicine (U.S.), Committe for the study on malaria prevention and control : status review and atternative strategies, κ.ά.
Έκδοση: (1991)

Akta pembasmi malaria, 1971

Malaria : genetic and evolutionary aspects /
ανά: Dronamraju, Krishna R., κ.ά.
Έκδοση: (2006)

Efficacy of Artesunate-mefloquine for Chloroquine-resistant Plasmodium vivax Malaria in Malaysia: An Open-label, Randomized, Controlled Trial
ανά: Grigg, Matthew J., κ.ά.
Έκδοση: (2016)

Sex and death: the effects of innate immune factors on the sexual reproduction of malaria parasites
ανά: Ramiro, R, κ.ά.
Έκδοση: (2011)

The engineer and the prevention of malaria /
ανά: 343398 Home, Henry
Έκδοση: (1926)

Malaria rides again
Έκδοση: (1979)

Malaria rides again
Έκδοση: (1979)

Malaria masih menjadi masalah/
ανά: 322123 Lokman Hakim Sulaiman, κ.ά.

Akta PEMBASMI Malaria (Pindaan) 1974.

Malaria rides again [kad apertur]
Έκδοση: (1979)

Metabolomic characterisation of acidosis in severe falciparum malaria
ανά: Leopold, S
Έκδοση: (2018)

Multiple functions of human T cells generated by experimental malaria challenge
ανά: Todryk, S, κ.ά.
Έκδοση: (2009)

Genomic epidemiology of malaria vectors in the Anopheles gambiae species complex
ανά: Miles, AJ
Έκδοση: (2021)

Comparison between survival and severe models of malaria infection for better understanding of the underlying disease pathogenesis
ανά: Chong, Wing Chui
Έκδοση: (2013)

The validation of chemical and immunological tests for antimalarials in body fluids : papers presented at a WHO/Universiti Sains Malaysia workshop /
ανά: 479901 Workshop on the Field Validation of Chemical and Immunological Tests for Antimalarials in Body Fluids (1990 : Pulau Pinang), κ.ά.
Έκδοση: (1990)

Antibodies against malaria and Epstein-Barr virus in childhood Burkitt lymphoma: a case-control study in Uganda
ανά: Carpenter, L, κ.ά.
Έκδοση: (2008)

Artemether-lumefantrine versus chloroquine for the treatment of uncomplicated Plasmodium knowlesi malaria : an open-label randomized controlled trial CAN KNOW
ανά: Grigg, Matthew J., κ.ά.
Έκδοση: (2020)

Immune responses to vaccines against malaria
ανά: Bliss, C
Έκδοση: (2017)

Population transcriptomics of human malaria parasites reveals the mechanism of artemisinin resistance
ανά: Mok, S., κ.ά.
Έκδοση: (2016)

Management of severe malaria in children: proposed guidelines for the United Kingdom
ανά: Maitland, K, κ.ά.
Έκδοση: (2005)

Influence of the number and timing of malaria episodes during pregnancy on prematurity and small for gestational age in an area of low malaria transmission
ανά: McGready, R
Έκδοση: (2017)

New approaches to pre-erythrocytic malaria vaccination
ανά: Mukhopadhyay, E
Έκδοση: (2021)

Metabolites of the kynurenine pathway of tryptophan metabolism in the cerebrospinal fluid of Malawian children with malaria
ανά: Medana, I, κ.ά.
Έκδοση: (2003)

From chloroquine to artemether-lumefantrine: the process of drug policy change in Zambia
ανά: Sipilanyambe, N, κ.ά.
Έκδοση: (2008)

Allelic heterogeneity of G6PD deficiency in West Africa and severe malaria susceptibility
ανά: Clark, T, κ.ά.
Έκδοση: (2009)

The effect of α (^+) - thalassaemia on the incidence of malaria and other diseases in children living on the coast of Kenya
ανά: Wambua, S, κ.ά.
Έκδοση: (2006)

Effects of interleukin-18 modulation on the pathogenesis of malaria infection
ανά: Jabbarzare, Marzieh
Έκδοση: (2013)

Inferring the transmission intensity of malaria using genetic data
ανά: Hendry, JA
Έκδοση: (2020)

Modelling malaria elimination on the internet
ανά: Maude, R, κ.ά.
Έκδοση: (2011)

Predictors of malaria among pregnant women attending ante-natal clinic in general hospital in Zamfara State, Nigeria
ανά: Hadiza, Kallamu
Έκδοση: (2015)

Health facility data to describe the epidemiology of malaria in sub-Saharan Africa
ανά: Kamau, A
Έκδοση: (2020)

Climatological and socioeconomic factors that predispose to the risk of malaria in Sudan
ανά: Mohammed, Ibrahim Musa Hassan
Έκδοση: (2012)

The relationship between age and the manifestations of and mortality associated with severe malaria
ανά: Dondorp, A, κ.ά.
Έκδοση: (2008)

Correlation of memory T cell responses against TRAP with protection from clinical malaria, and CD4^+ CD25 ^high T cells with susceptibility in Kenyans
ανά: Todryk, S, κ.ά.
Έκδοση: (2008)

Pharmacokinetics and pharmacodynamics of antimalarial drugs in pregnant women
ανά: Kloprogge, F
Έκδοση: (2013)

Targeting NAPE-PLD: assessing its potential in the fight against malaria
ανά: Goh, Xiu Ling
Έκδοση: (2024)

What you see is not what you get: implications of the brevity of antibody responses to malaria antigens and transmission heterogeneity in longitudinal studies of malaria immunity
ανά: Kinyanjui, S, κ.ά.
Έκδοση: (2009)