Major pitfalls in the measurement of artemisinin derivatives in plasma in clinical studies.

Major pitfalls in the measurement of artemisinin derivatives in plasma in clinical studies.

A bioanalytical method for the analysis of artesunate (ARS) and its metabolite dihydroartemisinin (DHA) in human plasma using protein precipitation and liquid chromatography coupled to positive tandem mass spectroscopy was developed. The method was validated according to published US FDA-guidelines...

Bibliográfalaš dieđut
Váldodahkkit:	Lindegardh, N, Hanpithakpong, W, Kamanikom, B, Singhasivanon, P, Socheat, D, Yi, P, Dondorp, A, Mcgready, R, Nosten, F, White, N, Day, N
Materiálatiipa:	Journal article
Giella:	English
Almmustuhtton:	2008

Geahča maid

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A liquid chromatographic-tandem mass spectrometric method for determination of artesunate and its metabolite dihydroartemisinin in human plasma.
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Intrahost modeling of artemisinin resistance in Plasmodium falciparum.
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Quantification of artemisinin in human plasma using liquid chromatography coupled to tandem mass spectrometry.
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Development and validation of a liquid chromatographic-tandem mass spectrometric method for determination of oseltamivir and its metabolite oseltamivir carboxylate in plasma, saliva and urine.
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Effect of high-dose or split-dose artesunate on parasite clearance in artemisinin-resistant falciparum malaria.
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Emergence of artemisinin-resistant malaria on the western border of Thailand: A longitudinal study
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Emergence of artemisinin-resistant malaria on the western border of Thailand: a longitudinal study
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Population pharmacokinetics of lumefantrine in pregnant women treated with artemether-lumefantrine for uncomplicated Plasmodium falciparum malaria.
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Artemisinin derivatives in the treatment of falciparum malaria in pregnancy.
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Validation and application of a liquid chromatographic-mass spectrometric method for determination of artesunate in pharmaceutical samples.
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Plasmodium falciparum-based bioassay for measurement of artemisinin derivatives in plasma or serum.
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Population pharmacokinetic and pharmacodynamic modeling of artemisinin resistance in Southeast Asia
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A major genome region underlying artemisinin resistance in malaria.
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Exploring the contribution of candidate genes to artemisinin resistance in Plasmodium falciparum.
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A major genome region underlying artemisinin resistance in malaria.
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Studies of the neurotoxicity of oral artemisinin derivatives in mice.
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Pitfalls in estimating piperaquine elimination.
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Optimising strategies for Plasmodium falciparum malaria elimination in Cambodia: primaquine, mass drug administration and artemisinin resistance.
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Rapid degradation of oseltamivir phosphate in clinical samples by plasma esterases.
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Comparison of plasma, venous and capillary blood levels of piperaquine in patients with uncomplicated falciparum malaria.
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Artemisinin resistance in Plasmodium falciparum is associated with an altered temporal pattern of transcription.
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Population pharmacokinetics of dihydroartemisinin and piperaquine in pregnant and nonpregnant women with uncomplicated malaria.
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Neuropathologic toxicity of artemisinin derivatives in a mouse model.
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Assessment of the neurotoxicity of parenteral artemisinin derivatives in mice.
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Effects of artemisinin derivatives on malaria transmissibility.
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Comparison of plasma, venous and capillary blood levels of piperaquine in patients with uncomplicated falciparum malaria
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