Vascular endothelial growth factor-C-mediated lymphangiogenesis promotes tumour metastasis.
Metastasis is a frequent and lethal complication of cancer. Vascular endothelial growth factor-C (VEGF-C) is a recently described lymphangiogenic factor. Increased expression of VEGF-C in primary tumours correlates with dissemination of tumour cells to regional lymph nodes. However, a direct role fo...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2001
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| _version_ | 1797091215196291072 |
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| author | Mandriota, S Jussila, L Jeltsch, M Compagni, A Baetens, D Prevo, R Banerji, S Huarte, J Montesano, R Jackson, D Orci, L Alitalo, K Christofori, G Pepper, MS |
| author_facet | Mandriota, S Jussila, L Jeltsch, M Compagni, A Baetens, D Prevo, R Banerji, S Huarte, J Montesano, R Jackson, D Orci, L Alitalo, K Christofori, G Pepper, MS |
| author_sort | Mandriota, S |
| collection | OXFORD |
| description | Metastasis is a frequent and lethal complication of cancer. Vascular endothelial growth factor-C (VEGF-C) is a recently described lymphangiogenic factor. Increased expression of VEGF-C in primary tumours correlates with dissemination of tumour cells to regional lymph nodes. However, a direct role for VEGF-C in tumour lymphangiogenesis and subsequent metastasis has yet to be demonstrated. Here we report the establishment of transgenic mice in which VEGF-C expression, driven by the rat insulin promoter (Rip), is targeted to beta-cells of the endocrine pancreas. In contrast to wild-type mice, which lack peri-insular lymphatics, RipVEGF-C transgenics develop an extensive network of lymphatics around the islets of Langerhans. These mice were crossed with Rip1Tag2 mice, which develop pancreatic beta-cell tumours that are neither lymphangiogenic nor metastatic. Double-transgenic mice formed tumours surrounded by well developed lymphatics, which frequently contained tumour cell masses of beta-cell origin. These mice frequently developed pancreatic lymph node metastases. Our findings demonstrate that VEGF-C-induced lymphangiogenesis mediates tumour cell dissemination and the formation of lymph node metastases. |
| first_indexed | 2024-03-07T03:29:47Z |
| format | Journal article |
| id | oxford-uuid:ba50ccc2-afd6-42db-b4e7-ea8411deb1fa |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:29:47Z |
| publishDate | 2001 |
| record_format | dspace |
| spelling | oxford-uuid:ba50ccc2-afd6-42db-b4e7-ea8411deb1fa2022-03-27T05:08:56ZVascular endothelial growth factor-C-mediated lymphangiogenesis promotes tumour metastasis.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:ba50ccc2-afd6-42db-b4e7-ea8411deb1faEnglishSymplectic Elements at Oxford2001Mandriota, SJussila, LJeltsch, MCompagni, ABaetens, DPrevo, RBanerji, SHuarte, JMontesano, RJackson, DOrci, LAlitalo, KChristofori, GPepper, MSMetastasis is a frequent and lethal complication of cancer. Vascular endothelial growth factor-C (VEGF-C) is a recently described lymphangiogenic factor. Increased expression of VEGF-C in primary tumours correlates with dissemination of tumour cells to regional lymph nodes. However, a direct role for VEGF-C in tumour lymphangiogenesis and subsequent metastasis has yet to be demonstrated. Here we report the establishment of transgenic mice in which VEGF-C expression, driven by the rat insulin promoter (Rip), is targeted to beta-cells of the endocrine pancreas. In contrast to wild-type mice, which lack peri-insular lymphatics, RipVEGF-C transgenics develop an extensive network of lymphatics around the islets of Langerhans. These mice were crossed with Rip1Tag2 mice, which develop pancreatic beta-cell tumours that are neither lymphangiogenic nor metastatic. Double-transgenic mice formed tumours surrounded by well developed lymphatics, which frequently contained tumour cell masses of beta-cell origin. These mice frequently developed pancreatic lymph node metastases. Our findings demonstrate that VEGF-C-induced lymphangiogenesis mediates tumour cell dissemination and the formation of lymph node metastases. |
| spellingShingle | Mandriota, S Jussila, L Jeltsch, M Compagni, A Baetens, D Prevo, R Banerji, S Huarte, J Montesano, R Jackson, D Orci, L Alitalo, K Christofori, G Pepper, MS Vascular endothelial growth factor-C-mediated lymphangiogenesis promotes tumour metastasis. |
| title | Vascular endothelial growth factor-C-mediated lymphangiogenesis promotes tumour metastasis. |
| title_full | Vascular endothelial growth factor-C-mediated lymphangiogenesis promotes tumour metastasis. |
| title_fullStr | Vascular endothelial growth factor-C-mediated lymphangiogenesis promotes tumour metastasis. |
| title_full_unstemmed | Vascular endothelial growth factor-C-mediated lymphangiogenesis promotes tumour metastasis. |
| title_short | Vascular endothelial growth factor-C-mediated lymphangiogenesis promotes tumour metastasis. |
| title_sort | vascular endothelial growth factor c mediated lymphangiogenesis promotes tumour metastasis |
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