Polymorphisms in the WNK1 gene are associated with blood pressure variation and urinary potassium excretion.

Polymorphisms in the WNK1 gene are associated with blood pressure variation and urinary potassium excretion.

WNK1--a serine/threonine kinase involved in electrolyte homeostasis and blood pressure (BP) control--is an excellent candidate gene for essential hypertension (EH). We and others have previously reported association between WNK1 and BP variation. Using tag SNPs (tSNPs) that capture 100% of common WN...

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Autors principals: Newhouse, S, Farrall, M, Wallace, C, Hoti, M, Burke, B, Howard, P, Onipinla, A, Lee, K, Shaw-Hawkins, S, Dobson, R, Brown, M, Samani, N, Dominiczak, A, Connell, J, Lathrop, G, Kooner, J, Chambers, J, Elliott, P, Clarke, R, Collins, R, Laan, M, Org, E, Juhanson, P, Veldre, G, Viigimaa, M, Eyheramendy, S, Cappuccio, F, Ji, C, Iacone, R, Strazzullo, P, Kumari, M, Marmot, M, Brunner, E, Caulfield, M, Munroe, P
Format: Journal article
Idioma:English
Publicat: Public Library of Science 2009

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