Molecular and cellular analysis of the membrane binding C2 domain of Notch ligands in health and disease

<p>The Notch signalling pathway is evolutionarily conserved across metazoan species and plays key roles in many physiological processes. Aberrant Notch signalling causes a wide variety of diseases including various cancers and developmental disorders. Both Notch ligands and receptors are singl...

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Bibliographic Details
Main Author: Meng, Y
Other Authors: Handford, P
Format: Thesis
Language:English
Published: 2021