Diastereoselective synthesis of 1,3,5-trisubstituted 4-nitropyrrolidin-2-ones via a nitro-Mannich/lactamization cascade.

Diastereoselective synthesis of 1,3,5-trisubstituted 4-nitropyrrolidin-2-ones via a nitro-Mannich/lactamization cascade.

A versatile one-pot nitro-Mannich/lactamization cascade for the direct synthesis of 1,3,5-trisubstituted 4-nitropyrrolidin-2-ones has been developed. The reaction is easy to perform and broad in scope, and high levels of diastereoselectivity can be achieved.

書目詳細資料
Main Authors:	Pelletier, S, Ray, P, Dixon, D
格式:	Journal article
語言:	English
出版:	2011

相似書籍

Nitro-Mannich/lactamization cascades for the direct stereoselective synthesis of pyrrolidin-2-ones.
由: Pelletier, S, et al.
出版: (2009)

Diastereoselective synthesis of pyrrolidine derivatives via a one-pot nitro-Mannich/hydroamination cascade using base and gold catalysis.
由: Ďuriš, A, et al.
出版: (2013)

Cyclic imine nitro-Mannich/lactamization cascades: a direct stereoselective synthesis of multicyclic piperidinone derivatives.
由: Jakubec, P, et al.
出版: (2008)

One-pot nitro-Mannich cascade reactions: new methodologies and synthetic applications
由: Pelletier, S, et al.
出版: (2011)

One-pot nitro-Mannich cascade reactions: new methodologies and synthetic applications
由: Pelletier, S, et al.
出版: (2011)

One-pot catalytic enantioselective synthesis of tetrahydropyridines via a nitro-Mannich/hydroamination cascade.
由: Barber, D, et al.
出版: (2012)

One-Pot Asymmetric Nitro-Mannich/Hydroamination Cascades for the Synthesis of Pyrrolidine Derivatives: Combining Organocatalysis and Gold Catalysis.
由: Barber, D, et al.
出版: (2014)

The development of nitro-Mannich/hydroamination cascades for the synthesis of substituted N-heterocycles
由: Barber, D, et al.
出版: (2013)

Stereoselective, nitro-Mannich/lactamisation cascades for the direct synthesis of heavily decorated 5-nitropiperidin-2-ones and related heterocycles.
由: Jakubec, P, et al.
出版: (2012)

One-pot nitro-Mannich/hydroamination cascades for the direct synthesis of 2,5-disubstituted pyrroles using base and gold catalysis.
由: Barber, D, et al.
出版: (2011)

Direct catalytic enantio- and diastereoselective Mannich reaction of isocyanoacetates and ketimines.
由: Ortín, I, et al.
出版: (2014)

A new family of cinchona-derived bifunctional asymmetric phase-transfer catalysts: application to the enantio- and diastereoselective nitro-Mannich reaction of amidosulfones.
由: Johnson, K, et al.
出版: (2012)

Catalytic enantio- and diastereoselective mannich addition of TosMIC to ketimines
由: Franchino, A, et al.
出版: (2018)

Iridium-catalyzed reductive nitro-Mannich cyclization.
由: Gregory, A, et al.
出版: (2015)

Diastereoselective reduction of cyclic bioactive Mannich ketones
由: Tamás Lóránda, et al.
出版: (2003-11-01)

Bifunctional iminophosphorane organocatalysts for enantioselective synthesis: application to the ketimine nitro-Mannich reaction.
由: Núñez, MG, et al.
出版: (2013)

Catalytic enantio- and diastereoselective Mannich reaction of α-substituted isocyanoacetates and ketimines.
由: de la Campa, R, et al.
出版: (2016)

On the diastereoselectivity of alkylations of bicyclic lactams
由: Bailey, J, et al.
出版: (2000)

Direct catalytic diastereoselective Mannich reactions: the synthesis of protected alpha-hydroxy-beta-aminoketones
由: Stainforth, N, et al.
出版: (2009)

Organocatalytic asymmetric Mannich reactions of 5H-oxazol-4-ones : highly enantio- and diastereoselective synthesis of chiral α-alkylisoserine derivatives
由: Han, Zhiqiang, et al.
出版: (2014)

Design and Synthesis of New 1,3,5‐Trisubstituted Triazines for the Treatment of Cancer and Inflammation
由: Dr. Boulos Zacharie, et al.
出版: (2018-09-01)

Trisubstituted 1,3,5-Triazines and Their Effect on BACE1
由: Petra Majerova, et al.
出版: (2023-11-01)

Sulfonated asphaltene as a highly efficient catalyst for the Mannich reaction with excellent diastereoselectivity and recyclability
由: Navid Habibnejad, et al.
出版: (2024-12-01)

Base and copper(I) catalyzed Mannich, alkyne hydroamination cascades for the direct synthesis of 2-methylenepyrrolidines.
由: Wang, H, et al.
出版: (2009)

Design, Synthesis, and In Vitro Antioxidant Activity of 1,3,5-Trisubstituted-2-pyrazolines Derivatives
由: P. C. Jagadish, et al.
出版: (2013-01-01)

Synthesis, carbonic anhydrase I and II inhibition studies of the 1,3,5-trisubstituted-pyrazolines
由: Halise Inci Gul, et al.
出版: (2017-01-01)

Synthesis and characterization of novel benzimidazole embedded 1,3,5-trisubstituted pyrazolines as antimicrobial agents
由: Padhy Gopal K., et al.
出版: (2017-01-01)

Diastereoselective Ugi reaction of chiral 1,3-aminoalcohols derived from an organocatalytic Mannich reaction
由: Samantha Caputo, et al.
出版: (2016-01-01)

Synthesis of the reported structure of piperazirum using a nitro-Mannich reaction as the key stereochemical determining step
由: James C. Anderson, et al.
出版: (2013-08-01)

One-pot multicomponent nitro-Mannich reaction using a heterogeneous catalyst under solvent-free conditions
由: Giovanna Bosica, et al.
出版: (2018-06-01)

Dearomatization of 3,5-dinitropyridines – an atom-efficient approach to fused 3-nitropyrrolidines
由: Maxim A. Bastrakov, et al.
出版: (2017-06-01)

[4-(4-Methoxyphenyl)-1-methyl-3-nitropyrrolidin-3-yl]methanol
由: M. Bakthadoss, et al.
出版: (2013-03-01)

Catalytic Asymmetric Nitro-Mannich Reactions with a Yb/K Heterobimetallic Catalyst
由: Tatsuya Nitabaru, et al.
出版: (2010-03-01)

Direct enantio- and diastereoselective Mannich reactions of malonate and beta-keto esters with N-Boc and N-Cbz aldimines catalysed by a bifunctional cinchonine derivative.
由: Tillman, A, et al.
出版: (2006)

Enantio- and diastereoselective Michael additions of C-succinimidyl esters to nitro olefins using cinchonine-derived bifunctional organocatalysts
由: Jakubec, P, et al.
出版: (2011)

cis-Diastereoselective Synthesis of Spirooxindolo-β-Lactams by Staudinger Cycloaddition with TsCl as Activating Co-reagent
由: Vadim E. Filatov, et al.
出版: (2021-08-01)

Enantioselective silver-catalyzed cascade synthesis of fused lactone and lactam oxazolines
由: De La Campa, R, et al.
出版: (2018)

Synthesis of substituted γ- and δ-lactams through mannich-type reactions of solid-supported N -acyliminium ions
由: Komnatnyy, Vitaly V., et al.
出版: (2015)

Enantio- and diastereoselective palladium catalysed arylative and vinylative allene carbocyclisation cascades.
由: Li, M, et al.
出版: (2013)

Crystal Structures and Optical Properties of Two Novel 1,3,5-Trisubstituted Pyrazoline Derivatives
由: Qi Feng, et al.
出版: (2018-12-01)