Persistent global inflammation caused by the loss of SIRT1 protects against experimental osteoarthritis

Inflammatory pathways have been attributed to play a central role in the pathogenesis of osteoarthritis (OA). However, most previous studies using knockout (KO) mice to inactivate inflammatory genes have showed no significant protection in experimental OA. In addition, biologic treatments targeting...

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Bibliografiske detaljer
Main Authors: Sacitharan, P, Zarebska, JM, Stott, BA, Parisi, I, Curtinha, MST, Bou-Gharios, G, Edwards, JR, Vincent, TL
Format: Conference item
Udgivet: Elsevier 2017