A conserved role for cytoplasmic poly(A)-binding protein 1 (PABPC1) in nonsense-mediated mRNA decay.

A conserved role for cytoplasmic poly(A)-binding protein 1 (PABPC1) in nonsense-mediated mRNA decay.

The nonsense-mediated mRNA decay (NMD) pathway degrades mRNAs with premature translation termination codons (PTCs). The mechanisms by which PTCs and natural stop codons are discriminated remain unclear. We show that the position of stops relative to the poly(A) tail (and thus of PABPC1) is a critica...

Полное описание

Библиографические подробности
Главные авторы:	Behm-Ansmant, I, Gatfield, D, Rehwinkel, J, Hilgers, V, Izaurralde, E
Формат:	Journal article
Язык:	English
Опубликовано:	2007

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