Chronic palmitate exposure inhibits insulin secretion by dissociation of Ca(2+) channels from secretory granules.

Long-term (72 hr) exposure of pancreatic islets to palmitate inhibited glucose-induced insulin secretion by >50% with first- and second-phase secretion being equally suppressed. This inhibition correlated with the selective impairment of exocytosis evoked by brief (action potential-like) depo...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron: Hoppa, M, Collins, S, Ramracheya, R, Hodson, L, Amisten, S, Zhang, Q, Johnson, P, Ashcroft, F, Rorsman, P
Fformat: Journal article
Iaith:English
Cyhoeddwyd: 2009