Expression of Ca²⁺-permeable two-pore channels rescues NAADP signalling in TPC-deficient cells.
The second messenger NAADP triggers Ca2+ release from endo‐lysosomes. Although two‐pore channels (TPCs) have been proposed to be regulated by NAADP, recent studies have challenged this. By generating the first mouse line with demonstrable absence of both Tpcn1 and Tpcn2 expression (Tpcn1/2−/−), we s...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Published: |
EMBO Press
2015
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