Multiple cutaneous malignancies arising in limbs with signs of lymphatic insufficiency in transplant patients.
We report the cases of four renal transplant patients who developed multiple skin cancers located preferentially on lymphoedematous lower limbs. All skin tumours appeared post-transplant and the diagnosis was confirmed on histologic examination. In addition, one of the patients also underwent mastec...
| Main Authors: | , , |
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| Format: | Journal article |
| Jezik: | English |
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1999
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| _version_ | 1826293758977638400 |
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| author | Bordea, C Wojnarowska, F Morris, P |
| author_facet | Bordea, C Wojnarowska, F Morris, P |
| author_sort | Bordea, C |
| collection | OXFORD |
| description | We report the cases of four renal transplant patients who developed multiple skin cancers located preferentially on lymphoedematous lower limbs. All skin tumours appeared post-transplant and the diagnosis was confirmed on histologic examination. In addition, one of the patients also underwent mastectomy with axillary dissection and radiotherapy for a left breast ductal carcinoma and subsequently developed multiple squamous carcinomas and intraepithelial carcinomas on the left upper limb.The aetiology of lymphoedema in these patients is multifactorial. In addition to immunosuppression, ultraviolet exposure, genetic factors and possibly infection with the human papilloma virus, which are thought to have a role in the aetiology of certain skin tumours, lymphoedema may have contributed to the predominant location of these skin malignancies on the lymphoedematous limbs. |
| first_indexed | 2024-03-07T03:35:06Z |
| format | Journal article |
| id | oxford-uuid:bc058d33-5f3a-4a0a-bee8-48a77737a97a |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:35:06Z |
| publishDate | 1999 |
| record_format | dspace |
| spelling | oxford-uuid:bc058d33-5f3a-4a0a-bee8-48a77737a97a2022-03-27T05:21:18ZMultiple cutaneous malignancies arising in limbs with signs of lymphatic insufficiency in transplant patients.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:bc058d33-5f3a-4a0a-bee8-48a77737a97aEnglishSymplectic Elements at Oxford1999Bordea, CWojnarowska, FMorris, PWe report the cases of four renal transplant patients who developed multiple skin cancers located preferentially on lymphoedematous lower limbs. All skin tumours appeared post-transplant and the diagnosis was confirmed on histologic examination. In addition, one of the patients also underwent mastectomy with axillary dissection and radiotherapy for a left breast ductal carcinoma and subsequently developed multiple squamous carcinomas and intraepithelial carcinomas on the left upper limb.The aetiology of lymphoedema in these patients is multifactorial. In addition to immunosuppression, ultraviolet exposure, genetic factors and possibly infection with the human papilloma virus, which are thought to have a role in the aetiology of certain skin tumours, lymphoedema may have contributed to the predominant location of these skin malignancies on the lymphoedematous limbs. |
| spellingShingle | Bordea, C Wojnarowska, F Morris, P Multiple cutaneous malignancies arising in limbs with signs of lymphatic insufficiency in transplant patients. |
| title | Multiple cutaneous malignancies arising in limbs with signs of lymphatic insufficiency in transplant patients. |
| title_full | Multiple cutaneous malignancies arising in limbs with signs of lymphatic insufficiency in transplant patients. |
| title_fullStr | Multiple cutaneous malignancies arising in limbs with signs of lymphatic insufficiency in transplant patients. |
| title_full_unstemmed | Multiple cutaneous malignancies arising in limbs with signs of lymphatic insufficiency in transplant patients. |
| title_short | Multiple cutaneous malignancies arising in limbs with signs of lymphatic insufficiency in transplant patients. |
| title_sort | multiple cutaneous malignancies arising in limbs with signs of lymphatic insufficiency in transplant patients |
| work_keys_str_mv | AT bordeac multiplecutaneousmalignanciesarisinginlimbswithsignsoflymphaticinsufficiencyintransplantpatients AT wojnarowskaf multiplecutaneousmalignanciesarisinginlimbswithsignsoflymphaticinsufficiencyintransplantpatients AT morrisp multiplecutaneousmalignanciesarisinginlimbswithsignsoflymphaticinsufficiencyintransplantpatients |