High intrapatient HIV-1 evolutionary rate is associated with CCR5-to-CXCR4 coreceptor switch
In approximately 70% of individuals infected with HIV-1 subtype B, the virus switches coreceptor use from exclusively CCR5 use (R5 virus) to either inclusion of or exclusively CXCR4 use (X4 virus) during infection. This switch is associated with an accelerated loss of CD4 T-cells and a faster progre...
| Main Authors: | , , , , , , , , , |
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| Format: | Journal article |
| Published: |
2013
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