De Novo Synthesis of Racemic 4-Deoxy-4,4-difluoro- and 2,4-Dideoxy-2,4,4-trifluorohexosides

A range of racemic 4-deoxy-4,4-difluorinated carbohydrates were prepared by using a diversity-oriented de novo synthesis starting with three commercially available two-carbon building blocks. A common gem-difluorinated glycal was prepared in 35 % yield in seven steps, from which five different 4-deo...

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Bibliographic Details
Main Authors: Giuffredi, G, Bernet, B, Gouverneur, V
Format: Journal article
Language:English
Published: 2011