De Novo Synthesis of Racemic 4-Deoxy-4,4-difluoro- and 2,4-Dideoxy-2,4,4-trifluorohexosides
A range of racemic 4-deoxy-4,4-difluorinated carbohydrates were prepared by using a diversity-oriented de novo synthesis starting with three commercially available two-carbon building blocks. A common gem-difluorinated glycal was prepared in 35 % yield in seven steps, from which five different 4-deo...
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| Format: | Journal article |
| Language: | English |
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2011
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| _version_ | 1797091618035073024 |
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| author | Giuffredi, G Bernet, B Gouverneur, V |
| author_facet | Giuffredi, G Bernet, B Gouverneur, V |
| author_sort | Giuffredi, G |
| collection | OXFORD |
| description | A range of racemic 4-deoxy-4,4-difluorinated carbohydrates were prepared by using a diversity-oriented de novo synthesis starting with three commercially available two-carbon building blocks. A common gem-difluorinated glycal was prepared in 35 % yield in seven steps, from which five different 4-deoxy-4,4-difluoro- and 4-deoxy-2,4,4-trifluorohexopyranosides were accessed using well-established functional group manipulations. Copyright © 2011 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim. |
| first_indexed | 2024-03-07T03:35:37Z |
| format | Journal article |
| id | oxford-uuid:bc2db4c0-9919-4341-9102-af9361c84c83 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:35:37Z |
| publishDate | 2011 |
| record_format | dspace |
| spelling | oxford-uuid:bc2db4c0-9919-4341-9102-af9361c84c832022-03-27T05:22:27ZDe Novo Synthesis of Racemic 4-Deoxy-4,4-difluoro- and 2,4-Dideoxy-2,4,4-trifluorohexosidesJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:bc2db4c0-9919-4341-9102-af9361c84c83EnglishSymplectic Elements at Oxford2011Giuffredi, GBernet, BGouverneur, VA range of racemic 4-deoxy-4,4-difluorinated carbohydrates were prepared by using a diversity-oriented de novo synthesis starting with three commercially available two-carbon building blocks. A common gem-difluorinated glycal was prepared in 35 % yield in seven steps, from which five different 4-deoxy-4,4-difluoro- and 4-deoxy-2,4,4-trifluorohexopyranosides were accessed using well-established functional group manipulations. Copyright © 2011 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim. |
| spellingShingle | Giuffredi, G Bernet, B Gouverneur, V De Novo Synthesis of Racemic 4-Deoxy-4,4-difluoro- and 2,4-Dideoxy-2,4,4-trifluorohexosides |
| title | De Novo Synthesis of Racemic 4-Deoxy-4,4-difluoro- and 2,4-Dideoxy-2,4,4-trifluorohexosides |
| title_full | De Novo Synthesis of Racemic 4-Deoxy-4,4-difluoro- and 2,4-Dideoxy-2,4,4-trifluorohexosides |
| title_fullStr | De Novo Synthesis of Racemic 4-Deoxy-4,4-difluoro- and 2,4-Dideoxy-2,4,4-trifluorohexosides |
| title_full_unstemmed | De Novo Synthesis of Racemic 4-Deoxy-4,4-difluoro- and 2,4-Dideoxy-2,4,4-trifluorohexosides |
| title_short | De Novo Synthesis of Racemic 4-Deoxy-4,4-difluoro- and 2,4-Dideoxy-2,4,4-trifluorohexosides |
| title_sort | de novo synthesis of racemic 4 deoxy 4 4 difluoro and 2 4 dideoxy 2 4 4 trifluorohexosides |
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