High Erk activity suppresses expression of the cell cycle inhibitor p27Kip1 in colorectal cancer cells.

High Erk activity suppresses expression of the cell cycle inhibitor p27Kip1 in colorectal cancer cells.

The molecular heterogeneity of human cancer cells at the level of signaling protein activities remains poorly understood. Using a panel of 64 colorectal (CRC) cancer cell lines the activity status of the MAP kinases Erk1 and Erk2 was investigated. Erk1/2 activity varied greatly within the CRC cell...

书目详细资料
Main Authors:	Kress, T, Raabe, T, Feller, S
格式:	Journal article
语言:	English
出版:	2010

相似书籍

High Erk activity suppresses expression of the cell cycle inhibitor p27Kip1 in colorectal cancer cells
由: Raabe Thomas, et al.
出版: (2010-02-01)

Low expression of the cell cycle inhibitor p27Kip1 in normal corticotroph cells, corticotroph tumors, and malignant pituitary tumors.
由: Lidhar, K, et al.
出版: (1999)

Cyclin-dependent kinase inhibitor p27Kip1 expression and interaction with other cell cycle-associated proteins in mammary carcinoma.
由: Gillett, C, et al.
出版: (1999)

High level expression of p27(kip1) and cyclin D1 in some human breast cancer cells: inverse correlation between the expression of p27(kip1) and degree of malignancy in human breast and colorectal cancers.
由: Fredersdorf, S, et al.
出版: (1997)

Docosahexaenoic acid inhibits cancer cell growth via p27Kip1, CDK2, ERK1/ERK2, and retinoblastoma phosphorylation
由: Naim A. Khan, et al.
出版: (2006-10-01)

Screening For Small Molecule Inhibitors Of p27Kip1 Degradation
由: Ooi, Li Ching
出版: (2012)

p27(kip1) localisation is an independent prognostic marker for colorectal cancer.
由: Royds, J, et al.
出版: (1997)

p27kip1 expression and phosphorylation dictate Palbociclib sensitivity in KRAS-mutated colorectal cancer
由: Gian Luca Rampioni Vinciguerra, et al.
出版: (2021-10-01)

The Cell Cycle Inhibitors p21Cip1 and p27Kip1 Control Proliferation but Enhance DNA Damage Resistance of Glioma Stem Cells
由: Olivia Morris-Hanon, et al.
出版: (2017-07-01)

KIF14 affects cell cycle arrest and cell viability in cervical cancer by regulating the p27Kip1 pathway
由: Jie Zhang, et al.
出版: (2022-04-01)

Connexin32 inhibits gastric carcinogenesis through cell cycle arrest and altered expression of p21Cip1 and p27Kip1
由: Hyang Jee, et al.
出版: (2013-01-01)

Loss of p27Kip1 expression in high grade human prostate adenocarcinoma
由: MOHD ROHAIZAD MD. RODUAN, et al.
出版: (2014-08-01)

Over-expression of BMPR-IB reduces the malignancy of glioblastoma cells by upregulation of p21 and p27Kip1
由: Liu Shuang, et al.
出版: (2012-05-01)

Hydrangenol suppresses VEGF-stimulated angiogenesis by targeting p27KIP1-dependent G1-cell cycle arrest, VEGFR-2-mediated signaling, and MMP-2 expression
由: Yujeong Gho, et al.
出版: (2019-03-01)

Cell type-specific effects of p27KIP1 loss on retinal development
由: Mariko Ogawa, et al.
出版: (2017-09-01)

Prognostic value of p27<sup>Kip1 </sup>expression in Basaloid Squamous Cell Carcinoma of the larynx
由: Galli Vieri, et al.
出版: (2006-06-01)

Stimulation of c-Jun/AP-1-Activity by the Cell Cycle Inhibitor p57Kip2
由: Michael Keith Kullmann, et al.
出版: (2021-04-01)

Mutation and expression analysis of the p27/kip1 gene in corticotrophin-secreting tumours.
由: Dahia, P, et al.
出版: (1998)

Regulation of p27<sup>Kip1</sup> and p57<sup>Kip2</sup> Functions by Natural Polyphenols
由: Gian Luigi Russo, et al.
出版: (2020-09-01)

Antiproliferative function of p27kip1 is frequently inhibited in highly malignant Burkitt's lymphoma cells.
由: Barnouin, K, et al.
出版: (1999)

Nucleocytoplasmic p27Kip1 Export Is Required for ERK1/2-Mediated Reactive Astroglial Proliferation Following Status Epilepticus
由: Ji-Eun Kim, et al.
出版: (2018-06-01)

Rp58 and p27kip1 coordinate cell cycle exit and neuronal migration within the embryonic mouse cerebral cortex
由: Olivier Clément, et al.
出版: (2017-05-01)

p27Kip1 Is Required to Mediate a G1 Cell Cycle Arrest Downstream of ATM following Genotoxic Stress.
由: Erica K Cassimere, et al.
出版: (2016-01-01)

Accelerated turnover of taste bud cells in mice deficient for the cyclin-dependent kinase inhibitor p27<sup>Kip1</sup>
由: Perna Marla K, et al.
出版: (2011-04-01)

Immunohistochemical Expression of p27<sup>Kip1</sup>, p57<sup>Kip2</sup>, Cyclin D1, Nestin, and Ki-67 in Ependymoma
由: Shahad Iqneibi, et al.
出版: (2022-02-01)

p27KIP1 Deletions in Childhood Acute Lymphoblastic Leukemia
由: Hiroaki Komuro, et al.
出版: (1999-08-01)

p27kip1 at the crossroad between actin and microtubule dynamics
由: Gian Luca Rampioni Vinciguerra, et al.
出版: (2019-04-01)

In vivo monitoring of intranuclear p27(kip1) protein expression in breast cancer cells during trastuzumab (Herceptin) therapy.
由: Cornelissen, B, et al.
出版: (2009)

The role of p27(Kip1) in dasatinib-enhanced paclitaxel cytotoxicity in human ovarian cancer cells.
由: Le, X, et al.
出版: (2011)

Phosphorylation and subcellular localization of p27Kip1 regulated by hydrogen peroxide modulation in cancer cells.
由: Irene L Ibañez, et al.
出版: (2012-01-01)

GATA3 maintains the quiescent state of cochlear supporting cells by regulating p27kip1
由: Jiadong Xu, et al.
出版: (2021-08-01)

Expression of transforming growth factor-beta-1 and p27<sup>Kip1 </sup>in pancreatic adenocarcinomas: relation with cell-cycle-associated proteins and clinicopathologic characteristics
由: Soyturk Mujde, et al.
出版: (2005-08-01)

Correction to: Rp58 and p27kip1 coordinate cell cycle exit and neuronal migration within the embryonic mouse cerebral cortex
由: Olivier Clément, et al.
出版: (2018-01-01)

High-throughput screening reveals alsterpaullone, 2-cyanoethyl as a potent p27Kip1 transcriptional inhibitor.
由: Brandon J Walters, et al.
出版: (2014-01-01)

Degradation of p27(Kip) cdk inhibitor triggered by Kaposi's sarcoma virus cyclin-cdk6 complex.
由: Ellis, M, et al.
出版: (1999)

Levels of expression of p27KIP1 protein in human prostate and prostate cancer: an immunohistochemical analysis.
由: Erdamar, S, et al.
出版: (1999)

Effect of Xpcl1 activation and p27(Kip1) loss on gene expression in murine lymphoma.
由: Daniel A Kuppers, et al.
出版: (2011-03-01)

PRMT5 is upregulated in malignant and metastatic melanoma and regulates expression of MITF and p27(Kip1.).
由: Courtney Nicholas, et al.
出版: (2013-01-01)

Akt/p27kip1 Pathway Is Not Involved in Human Insulinoma Tumorigenesis
由: Adriana Graciela Díaz, et al.
出版: (2018-01-01)

p27<sup>kip1</sup>: a target for tumor therapies?
由: Kossatz Uta, et al.
出版: (2007-05-01)