Discovery of BET bromodomain inhibitors and their role in target validation
Bromodomains (BRDs) are protein interaction modules that selectively recognize ε-N-acetylated lysine residues. BRDs are present in diverse proteins that play key functions in chromatin organization and regulation of gene transcription. Aberrant transcription is a hallmark of many diseases in particu...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Royal Society of Chemistry
2014
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