Update on mutations in glucokinase (GCK), which cause maturity-onset diabetes of the young, permanent neonatal diabetes, and hyperinsulinemic hypoglycemia.

Update on mutations in glucokinase (GCK), which cause maturity-onset diabetes of the young, permanent neonatal diabetes, and hyperinsulinemic hypoglycemia.

Glucokinase is a key regulatory enzyme in the pancreatic beta-cell. It plays a crucial role in the regulation of insulin secretion and has been termed the glucose sensor in pancreatic beta-cells. Given its central role in the regulation of insulin release it is understandable that mutations in the g...

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Príomhchruthaitheoirí:	Osbak, K, Colclough, K, Saint-Martin, C, Beer, N, Bellanné-Chantelot, C, Ellard, S, Gloyn, A
Formáid:	Journal article
Teanga:	English
Foilsithe / Cruthaithe:	2009

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Complete glucokinase deficiency is not a common cause of permanent neonatal diabetes.
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Phenotypic heterogeneity in a family with a novel activating glucokinase (GCK) mutation (G68V) causing familial persistent hyperinsulinaemic hypoglycaemia of infancy
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Octreotide-Treated Diabetes Accompanied by Endogenous Hyperinsulinemic Hypoglycemia and Protein-Losing Gastroenteropathy
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Diazoxide for Neonatal Hyperinsulinemic Hypoglycemia and Pulmonary Hypertension
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Hyperinsulinemic hypoglycemia in adolescents: case report and systematic review
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