Update on mutations in glucokinase (GCK), which cause maturity-onset diabetes of the young, permanent neonatal diabetes, and hyperinsulinemic hypoglycemia.

Update on mutations in glucokinase (GCK), which cause maturity-onset diabetes of the young, permanent neonatal diabetes, and hyperinsulinemic hypoglycemia.

Glucokinase is a key regulatory enzyme in the pancreatic beta-cell. It plays a crucial role in the regulation of insulin secretion and has been termed the glucose sensor in pancreatic beta-cells. Given its central role in the regulation of insulin release it is understandable that mutations in the g...

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Dettagli Bibliografici
Autori principali:	Osbak, K, Colclough, K, Saint-Martin, C, Beer, N, Bellanné-Chantelot, C, Ellard, S, Gloyn, A
Natura:	Journal article
Lingua:	English
Pubblicazione:	2009

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