Soluble plasma programmed death 1 (PD-1) and Tim-3 in primary HIV infection

Soluble plasma programmed death 1 (PD-1) and Tim-3 in primary HIV infection

Soluble forms of the coinhibitory receptors programmed death 1 (PD-1) and Tim-3 exist, but their relationship with T-cell surface expression remains unclear. When measured by an enzyme-linked immunosorbent assay in plasma, soluble PD-1, and soluble Tim-3 were elevated during primary HIV infection, d...

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Bibliographic Details
Main Authors: Frater, J, Martin, GE, Willberg, CB, Zilber, E, Fox, J, Nwokolo, N, Fidler, S, CHERUB Investigators
Format: Journal article
Language:English
Published: Lippincott, Williams & Wilkins 2019
Description
Summary:Soluble forms of the coinhibitory receptors programmed death 1 (PD-1) and Tim-3 exist, but their relationship with T-cell surface expression remains unclear. When measured by an enzyme-linked immunosorbent assay in plasma, soluble PD-1, and soluble Tim-3 were elevated during primary HIV infection, decreased on antiretroviral therapy to levels found in controls, and correlated with cell surface expression. We conclude that soluble PD-1 and soluble Tim-3 are easy to measure biomarkers of immune exhaustion which potentially eliminate the need for flow cytometry.

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