The de novo selection of drug-resistant malaria parasites.
Antimalarial drug resistance emerges de novo predominantly in areas of low malaria transmission. Because of the logarithmic distribution of parasite numbers in human malaria infections, inadequately treated high biomass infections are a major source of de novo antimalarial resistance, whereas use of...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
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2003
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| _version_ | 1797091852477792256 |
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| author | White, N Pongtavornpinyo, W |
| author_facet | White, N Pongtavornpinyo, W |
| author_sort | White, N |
| collection | OXFORD |
| description | Antimalarial drug resistance emerges de novo predominantly in areas of low malaria transmission. Because of the logarithmic distribution of parasite numbers in human malaria infections, inadequately treated high biomass infections are a major source of de novo antimalarial resistance, whereas use of antimalarial prophylaxis provides a low resistance selection risk. Slowly eliminated antimalarials encourage resistance largely by providing a selective filter for resistant parasites acquired from others, and not by selecting resistance de novo. The de novo emergence of resistance can be prevented by use of antimalarial combinations. Artemisinin derivative combinations are particularly effective. Ensuring adequate treatment of the relatively few heavily infected patients would slow the emergence of resistance. |
| first_indexed | 2024-03-07T03:38:15Z |
| format | Journal article |
| id | oxford-uuid:bd041adb-44e9-439e-8b3d-631246b1f6c2 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:38:15Z |
| publishDate | 2003 |
| record_format | dspace |
| spelling | oxford-uuid:bd041adb-44e9-439e-8b3d-631246b1f6c22022-03-27T05:28:38ZThe de novo selection of drug-resistant malaria parasites.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:bd041adb-44e9-439e-8b3d-631246b1f6c2EnglishSymplectic Elements at Oxford2003White, NPongtavornpinyo, WAntimalarial drug resistance emerges de novo predominantly in areas of low malaria transmission. Because of the logarithmic distribution of parasite numbers in human malaria infections, inadequately treated high biomass infections are a major source of de novo antimalarial resistance, whereas use of antimalarial prophylaxis provides a low resistance selection risk. Slowly eliminated antimalarials encourage resistance largely by providing a selective filter for resistant parasites acquired from others, and not by selecting resistance de novo. The de novo emergence of resistance can be prevented by use of antimalarial combinations. Artemisinin derivative combinations are particularly effective. Ensuring adequate treatment of the relatively few heavily infected patients would slow the emergence of resistance. |
| spellingShingle | White, N Pongtavornpinyo, W The de novo selection of drug-resistant malaria parasites. |
| title | The de novo selection of drug-resistant malaria parasites. |
| title_full | The de novo selection of drug-resistant malaria parasites. |
| title_fullStr | The de novo selection of drug-resistant malaria parasites. |
| title_full_unstemmed | The de novo selection of drug-resistant malaria parasites. |
| title_short | The de novo selection of drug-resistant malaria parasites. |
| title_sort | de novo selection of drug resistant malaria parasites |
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