D-chiro-inositol ribophostin: a highly potent agonist at D-myo-inositol 1,4,5-trisphosphate receptors: synthesis and biological activities

Analogues of the Ca2+-releasing intracellular messenger D-myo-inositol 1,4,5-trisphosphate [1, Ins(1,4,5)P3] are important synthetic targets. Replacement of the α-glucopyranosyl motif in the natural product mimic adenophostin 2 by D-chiro-inositol in D-chiro-inositol adenophostin 4 increased potency...

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Autori principali: Mills, S, Rossi, AM, Konieczny, V, Bakowski, D, Taylor, CW, Potter, BVL
Natura: Journal article
Lingua:English
Pubblicazione: American Chemical Society 2020