A molecular mechanism of mitotic centrosome assembly in Drosophila

A molecular mechanism of mitotic centrosome assembly in Drosophila

Centrosomes comprise a pair of centrioles surrounded by pericentriolar material (PCM). The PCM expands dramatically as cells enter mitosis, but it is unclear how this occurs. In this study, we show that the centriole protein Asl initiates the recruitment of DSpd-2 and Cnn to mother centrioles; both...

Full description

Bibliographic Details
Main Authors:	Conduit, PT, Richens, JH, Wainman, A, Holder, J, Vicente, CC, Pratt, MB, Dix, CI, Novak, ZA, Dobbie, IM, Schermelleh, L, Raff, JW
Format:	Journal article
Language:	English
Published:	eLife Sciences Publications 2014

Similar Items

A molecular mechanism of mitotic centrosome assembly in Drosophila
by: Paul T Conduit, et al.
Published: (2014-08-01)

Re-examining the role of Drosophila Sas-4 in centrosome assembly using two-colour-3D-SIM FRAP
by: Conduit, PT, et al.
Published: (2015)

Drosophila Sas-6, Ana2 and Sas-4 self-organise into macromolecular structures that can be used to probe centriole and centrosome assembly
by: Gartenmann, L, et al.
Published: (2020)

Different Drosophila cell types exhibit differences in mitotic centrosome assembly dynamics.
by: Conduit, P, et al.
Published: (2015)

Structural basis for mitotic centrosome assembly in flies
by: Feng, Z, et al.
Published: (2017)

Evidence that a positive feedback loop drives centrosome maturation in fly embryos
by: Alvarez-Rodrigo, I, et al.
Published: (2019)

Centrosome function and assembly in animal cells
by: Conduit, P, et al.
Published: (2015)

The centrosome-specific phosphorylation of Cnn by Polo/Plk1 drives Cnn scaffold assembly and centrosome maturation.
by: Conduit, P, et al.
Published: (2014)

Cnn dynamics drive centrosome size asymmetry to ensure daughter centriole retention in Drosophila neuroblasts.
by: Conduit, P, et al.
Published: (2010)

Cdk1 phosphorylates Drosophila Sas-4 to recruit Polo to daughter centrioles and convert them to centrosomes
by: Raff, J, et al.
Published: (2016)

Drosophila Ana1 is required for centrosome assembly and centriole elongation
by: Saurya, S, et al.
Published: (2016)

A positive feedback loop drives centrosome maturation in flies
by: Alvarez Rodrigo, I, et al.
Published: (2018)

Asterless licenses daughter centrioles to duplicate for the first time in Drosophila embryos.
by: Novak, Z, et al.
Published: (2014)

Centrioles regulate centrosome size by controlling the rate of Cnn incorporation into the PCM.
by: Conduit, P, et al.
Published: (2010)

Ana1 helps recruit Polo to centrioles to promote mitotic PCM assembly and centriole elongation
by: Alvarez-Rodrigo, I, et al.
Published: (2021)

The Drosophila Pericentrin-like-protein (PLP) cooperates with Cnn to maintain the integrity of the outer PCM
by: Richens, J, et al.
Published: (2015)

The role and regulation of Asterless in the centrosome cycle
by: Novak, ZA
Published: (2014)

The dominant force of Centrobin in centrosome asymmetry.
by: Conduit, P
Published: (2013)

Centrosome loss or amplification does not dramatically perturb global gene expression in Drosophila.
by: Baumbach, J, et al.
Published: (2012)

LK6, a short lived protein kinase in Drosophila that can associate with microtubules and centrosomes.
by: Kidd, D, et al.
Published: (1997)

Centrosomes have a role in regulating the destruction of cyclin B in early Drosophila embryos.
by: Wakefield, J, et al.
Published: (2000)

Centrioles generate a local pulse of Polo/PLK1 activity to initiate mitotic centrosome assembly
by: Wong, S-S, et al.
Published: (2022)

Studying centrosome formation and the consequences of centrosome loss in Drosophila melanogaster
by: Baumbach, J
Published: (2014)

Centrosomes: Central no more?
by: Raff, J
Published: (2001)

Drosophila Cep135/Bld10 maintains proper centriole structure but is dispensable for cartwheel formation.
by: Roque, H, et al.
Published: (2012)

LK6, a novel Drosophila protein kinase that is rapidly turned over and is associated with microtubules and centrosomes.
by: Kidd, D, et al.
Published: (1996)

The centrosomal protein CP190 regulates myosin function during early Drosophila development.
by: Chodagam, S, et al.
Published: (2005)

Dissecting the function and assembly of acentriolar microtubule organizing centers in Drosophila cells in vivo
by: Baumbach, J, et al.
Published: (2015)

Centrosomal and Non-Centrosomal Microtubule-Organizing Centers (MTOCs) in Drosophila melanogaster
by: Marisa M. L. Tillery, et al.
Published: (2018-08-01)

The Drosophila centrosome-associated protein CP190 is essential for viability but not for cell division.
by: Butcher, R, et al.
Published: (2004)

A genome-wide RNAi screen to dissect centriole duplication and centrosome maturation in Drosophila
by: Dobbelaere, J, et al.
Published: (2008)

Centrosomes and microtubules: wedded with a ring.
by: Raff, J
Published: (1996)

Dynamical modeling of syncytial mitotic cycles in Drosophila embryos.
by: Calzone, L, et al.
Published: (2007)

SAPs as a new model to probe the pathway of centriole and centrosome assembly
by: Wainman, A
Published: (2021)

D-TACC: a novel centrosomal protein required for normal spindle function in the early Drosophila embryo.
by: Gergely, F, et al.
Published: (2000)

Drosophila Aurora A kinase is required to localize D-TACC to centrosomes and to regulate astral microtubules.
by: Giet, R, et al.
Published: (2002)

Phase separation and the centrosome: a fait accompli?
by: Raff, J
Published: (2019)

Centrosomes and cancer: lessons from a TACC.
by: Raff, J
Published: (2002)

Mathematical modelling of Centrosomin incorporation in Drosophila centrosomes
by: Bakshi, S
Published: (2013)

The dynamics of centrosome assembly in the early Drosophila embryo
by: Wong, SS
Published: (2021)