Chronic oral ascorbic acid therapy worsens skeletal muscle metabolism in patients with chronic heart failure.

BACKGROUND: Chronic heart failure (CHF) is associated with abnormalities of skeletal muscle metabolism. This may be due to impaired oxygen delivery as a result of endothelial dysfunction. AIMS: We postulated that ascorbic acid would improve oxygen delivery to exercising muscle and improve skeletal m...

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Bibliographic Details
Main Authors: Nightingale, A, Crilley, J, Pegge, N, Boehm, E, Mumford, C, Taylor, D, Styles, P, Clarke, K, Frenneaux, M
Format: Journal article
Language:English
Published: 2007