Activation of key profibrotic mechanisms in transgenic fibroblasts expressing kinase-deficient type II Transforming growth factor-{beta} receptor (T{beta}RII{delta}k).

Activation of key profibrotic mechanisms in transgenic fibroblasts expressing kinase-deficient type II Transforming growth factor-{beta} receptor (T{beta}RII{delta}k).

We have generated transgenic mice expressing a kinase-deficient type II transforming growth factor-beta (TGFbeta) receptor selectively on fibroblasts (TbetaRIIDeltak-fib). These mice develop dermal and pulmonary fibrosis. In the present study we explore activation of TGFbeta signaling pathways in th...

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Những tác giả chính: Denton, C, Lindahl, G, Khan, K, Shiwen, X, Ong, V, Gaspar, N, Lazaridis, K, Edwards, DR, Leask, A, Eastwood, M, Leoni, P, Renzoni, E, Bou Gharios, G, Abraham, D, Black, C
Định dạng: Journal article
Ngôn ngữ:English
Được phát hành: 2005

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