Efficacy, pharmacokinetics, and metabolism of tetrahydroquinoline inhibitors of Plasmodium falciparum protein farnesyltransferase.

New antimalarials are urgently needed. We have shown that tetrahydroquinoline (THQ) protein farnesyltransferase (PFT) inhibitors (PFTIs) are effective against the Plasmodium falciparum PFT and are effective at killing P. falciparum in vitro. Previously described THQ PFTIs had limitations of poor ora...

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Bibliographic Details
Main Authors:	Van Voorhis, W, Rivas, K, Bendale, P, Nallan, L, Hornéy, C, Barrett, L, Bauer, K, Smart, B, Ankala, S, Hucke, O, Verlinde, C, Chakrabarti, D, Strickland, C, Yokoyama, K, Buckner, F, Hamilton, A, Williams, D, Lombardo, L, Floyd, D, Gelb, M
Format:	Journal article
Language:	English
Published:	2007

Efficacy, pharmacokinetics, and metabolism of tetrahydroquinoline inhibitors of Plasmodium falciparum protein farnesyltransferase.

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