On-microscope staging of live cells reveals changes in the dynamics of transcriptional bursting during differentiation

Determining the mechanisms by which genes are switched on and off during development is a key aim of current biomedical research. Gene transcription has been widely observed to occur in a discontinuous fashion, with short bursts of activity interspersed with periods of inactivity. It is currently no...

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Bibliographic Details
Main Authors: Jeziorska, DM, Tunnacliffe, EAJ, Brown, JM, Ayyub, H, Sloane-Stanley, J, Sharpe, JA, Lagerholm, BC, Babbs, C, Smith, AJH, Buckle, VJ, Higgs, DR
Format: Journal article
Language:English
Published: Springer Nature 2022
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