Leu-574 of human HIF-1alpha is a molecular determinant of prolyl hydroxylation.

Hypoxia-inducible factor (HIF)-1alpha, a master regulator of oxygen homeostasis, regulates genes crucial for cell growth and survival. In normoxia, HIF-1alpha is constantly degraded via the ubiquitin-proteasome pathway. The von Hippel-Lindau (VHL) E3 ubiquitin ligase binds HIF-1alpha through specifi...

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Autori principali: Kageyama, Y, Koshiji, M, To, K, Tian, Y, Ratcliffe, P, Huang, L
Natura: Journal article
Lingua:English
Pubblicazione: 2004