Associations of functional alanine-glyoxylate aminotransferase 2 gene variants with atrial fibrillation and ischemic stroke

Asymmetric and symmetric dimethylarginines (ADMA and SDMA) impair nitric oxide bioavailability and have been implicated in the pathogenesis of atrial fibrillation (AF). Alanine-glyoxylate aminotransferase 2 (AGXT2) is the only enzyme capable of metabolizing both of the dimethylarginines. We hypothes...

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書誌詳細
主要な著者: Seppälä, I, Kleber, M, Bevan, S, Lyytikäinen, L, Oksala, N, Hernesniemi, J, Mäkelä, K, Rothwell, P, Sudlow, C, Dichgans, M, Mononen, N, Vlachopoulou, E, Sinisalo, J, Delgado, G, Laaksonen, R, Koskinen, T, Scharnagl, H, Kähönen, M, Markus, H, März, W, Lehtimäki, T
フォーマット: Journal article
言語:English
出版事項: 2016