The majority of currently circulating human immunodeficiency virus type 1 clade B viruses fail to prime cytotoxic T-lymphocyte responses against an otherwise immunodominant HLA-A2-restricted epitope: implications for vaccine design.

Human immunodeficiency virus type 1 (HIV-1) mutates to escape immune selection pressure, but there is little evidence of selection mediated through HLA-A2, the dominant class I allele in persons infected with clade B virus. Moreover, HLA-A2-restricted responses are largely absent in the acute phase...

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Bibliographic Details
Main Authors:	Altfeld, M, Allen, T, Kalife, E, Frahm, N, Addo, M, Mothe, B, Rathod, A, Reyor, L, Harlow, J, Yu, X, Perkins, B, Robinson, L, Sidney, J, Alter, G, Lichterfeld, M, Sette, A, Rosenberg, E, Goulder, P, Brander, C, Walker, B
Format:	Journal article
Language:	English
Published:	2005

The majority of currently circulating human immunodeficiency virus type 1 clade B viruses fail to prime cytotoxic T-lymphocyte responses against an otherwise immunodominant HLA-A2-restricted epitope: implications for vaccine design.

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