Coordination of multiple enzyme activities by a single PCNA in archaeal Okazaki fragment maturation.

Chromosomal DNA replication requires one daughter strand-the lagging strand-to be synthesised as a series of discontinuous, RNA-primed Okazaki fragments, which must subsequently be matured into a single covalent DNA strand. Here, we describe the reconstitution of Okazaki fragment maturation in vitro...

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Bibliografiske detaljer
Main Authors: Beattie, T, Bell, S
Format: Journal article
Sprog:English
Udgivet: 2012