The pharmacology of bisphosphonates and new insights into their mechanisms of action.
Bisphosphonates are chemically stable analogs of inorganic pyrophosphate, which are resistant to breakdown by enzymatic hydrolysis. The biological effects of bisphosphonates on calcium metabolism were originally ascribed to their physico-chemical effects on hydroxyapatite crystals. Although such eff...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Conference item |
| Published: |
1999
|