The pharmacology of bisphosphonates and new insights into their mechanisms of action.
Bisphosphonates are chemically stable analogs of inorganic pyrophosphate, which are resistant to breakdown by enzymatic hydrolysis. The biological effects of bisphosphonates on calcium metabolism were originally ascribed to their physico-chemical effects on hydroxyapatite crystals. Although such eff...
| Main Authors: | , , , , , , , , |
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| Format: | Conference item |
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1999
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| _version_ | 1797092181605875712 |
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| author | Russell, R Rogers, M Frith, J Luckman, S Coxon, F Benford, H Croucher, P Shipman, C Fleisch, H |
| author_facet | Russell, R Rogers, M Frith, J Luckman, S Coxon, F Benford, H Croucher, P Shipman, C Fleisch, H |
| author_sort | Russell, R |
| collection | OXFORD |
| description | Bisphosphonates are chemically stable analogs of inorganic pyrophosphate, which are resistant to breakdown by enzymatic hydrolysis. The biological effects of bisphosphonates on calcium metabolism were originally ascribed to their physico-chemical effects on hydroxyapatite crystals. Although such effects may contribute to their overall action, their effects on cells are probably of greater importance, particularly for the more potent compounds. Remarkable progress has been made in increasing the potency of bisphosphonates as inhibitors of bone resorption, and the most potent compounds in current use are characterized by the presence of a nitrogen atom at critical positions in the side chain which, together with the bisphosphonate moiety itself, seems to be essential for maximal activity. As a class the bisphosphonates offer a very effective means of treating Paget's disease. |
| first_indexed | 2024-03-07T03:42:29Z |
| format | Conference item |
| id | oxford-uuid:be5ffeb7-ced3-440e-bdfe-5b5f9a268ff8 |
| institution | University of Oxford |
| last_indexed | 2024-03-07T03:42:29Z |
| publishDate | 1999 |
| record_format | dspace |
| spelling | oxford-uuid:be5ffeb7-ced3-440e-bdfe-5b5f9a268ff82022-03-27T05:38:56ZThe pharmacology of bisphosphonates and new insights into their mechanisms of action.Conference itemhttp://purl.org/coar/resource_type/c_5794uuid:be5ffeb7-ced3-440e-bdfe-5b5f9a268ff8Symplectic Elements at Oxford1999Russell, RRogers, MFrith, JLuckman, SCoxon, FBenford, HCroucher, PShipman, CFleisch, HBisphosphonates are chemically stable analogs of inorganic pyrophosphate, which are resistant to breakdown by enzymatic hydrolysis. The biological effects of bisphosphonates on calcium metabolism were originally ascribed to their physico-chemical effects on hydroxyapatite crystals. Although such effects may contribute to their overall action, their effects on cells are probably of greater importance, particularly for the more potent compounds. Remarkable progress has been made in increasing the potency of bisphosphonates as inhibitors of bone resorption, and the most potent compounds in current use are characterized by the presence of a nitrogen atom at critical positions in the side chain which, together with the bisphosphonate moiety itself, seems to be essential for maximal activity. As a class the bisphosphonates offer a very effective means of treating Paget's disease. |
| spellingShingle | Russell, R Rogers, M Frith, J Luckman, S Coxon, F Benford, H Croucher, P Shipman, C Fleisch, H The pharmacology of bisphosphonates and new insights into their mechanisms of action. |
| title | The pharmacology of bisphosphonates and new insights into their mechanisms of action. |
| title_full | The pharmacology of bisphosphonates and new insights into their mechanisms of action. |
| title_fullStr | The pharmacology of bisphosphonates and new insights into their mechanisms of action. |
| title_full_unstemmed | The pharmacology of bisphosphonates and new insights into their mechanisms of action. |
| title_short | The pharmacology of bisphosphonates and new insights into their mechanisms of action. |
| title_sort | pharmacology of bisphosphonates and new insights into their mechanisms of action |
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