Understanding functional miRNA-target interactions in vivo by site-specific genome engineering

MicroRNA (miRNA) target recognition is largely dictated by short ‘seed’ sequences, and single miRNAs therefore have the potential to regulate a large number of genes. Understanding the contribution of specific miRNA–target interactions to the regulation of biological processes in vivo remains challe...

Full description

Bibliographic Details
Main Authors: Bassett, A, Azzam, G, Wheatley, L, Tibbit, C, Rajakumar, T, McGowan, S, Stanger, N, Ewels, P, Taylor, S, Ponting, C, Liu, J, Sauka-Spengler, T, Fulga, T
Format: Journal article
Language:English
Published: Springer Nature 2014