Bosentan attenuates the profibrotic gene expression profile of lung fibroblasts in scleroderma

Eitemau Tebyg

• Bosentan alleviates the pro-fibrotic phenotype of lung scleroderma fibroblasts: Implications for treatment of scleroderma.
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• Endothelin is a downstream mediator of profibrotic responses to transforming growth factor beta in human lung fibroblasts.
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• Response of human lung fibroblast cells to stimulation by endothelin-1: Involvement of ras/MEK/ERK and PI3 kinase
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  Cyhoeddwyd: (2003)
• Endothelin-1 induces expression of matrix-associated genes in lung fibroblasts through MEK/ERK.
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  Cyhoeddwyd: (2004)
• Gene expression profiling reveals novel TGFbeta targets in adult lung fibroblasts.
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  Cyhoeddwyd: (2004)