Bosentan attenuates the profibrotic gene expression profile of lung fibroblasts in scleroderma

Geahča maid

• Bosentan alleviates the pro-fibrotic phenotype of lung scleroderma fibroblasts: Implications for treatment of scleroderma.
  Dahkki: Leask, A, et al.
  Almmustuhtton: (2005)
• Endothelin is a downstream mediator of profibrotic responses to transforming growth factor beta in human lung fibroblasts.
  Dahkki: Shi-wen, X, et al.
  Almmustuhtton: (2007)
• Response of human lung fibroblast cells to stimulation by endothelin-1: Involvement of ras/MEK/ERK and PI3 kinase
  Dahkki: Shiwen, X, et al.
  Almmustuhtton: (2003)
• Endothelin-1 induces expression of matrix-associated genes in lung fibroblasts through MEK/ERK.
  Dahkki: Xu, S, et al.
  Almmustuhtton: (2004)
• Gene expression profiling reveals novel TGFbeta targets in adult lung fibroblasts.
  Dahkki: Renzoni, E, et al.
  Almmustuhtton: (2004)