Critical residues for structure and catalysis in short-chain dehydrogenases/reductases.

Critical residues for structure and catalysis in short-chain dehydrogenases/reductases.

Short-chain dehydrogenases/reductases form a large, evolutionarily old family of NAD(P)(H)-dependent enzymes with over 60 genes found in the human genome. Despite low levels of sequence identity (often 10-30%), the three-dimensional structures display a highly similar alpha/beta folding pattern. We...

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Bibliographische Detailangaben
Hauptverfasser:	Filling, C, Berndt, K, Benach, J, Knapp, S, Prozorovski, T, Nordling, E, Ladenstein, R, Jörnvall, H, Oppermann, U
Format:	Journal article
Sprache:	English
Veröffentlicht:	2002

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